Prediction of Kidney Graft Rejection Using Artificial Neural Network
نویسندگان
چکیده
Objectives Kidney transplantation is the best renal replacement therapy for patients with end-stage renal disease. Several studies have attempted to identify predisposing factors of graft rejection; however, the results have been inconsistent. We aimed to identify prognostic factors associated with kidney transplant rejection using the artificial neural network (ANN) approach and to compare the results with those obtained by logistic regression (LR). Methods The study used information regarding 378 patients who had undergone kidney transplantation from a retrospective study conducted in Hamadan, Western Iran, from 1994 to 2011. ANN was used to identify potential important risk factors for chronic nonreversible graft rejection. Results Recipients' age, creatinine level, cold ischemic time, and hemoglobin level at discharge were identified as the most important prognostic factors by ANN. The ANN model showed higher total accuracy (0.75 vs. 0.55 for LR), and the area under the ROC curve (0.88 vs. 0.75 for LR) was better than that obtained with LR. Conclusions The results of this study indicate that the ANN model outperformed LR in the prediction of kidney transplantation failure. Therefore, this approach is a promising classifier for predicting graft failure to improve patients' survival and quality of life, and it should be further investigated for the prediction of other clinical outcomes.
منابع مشابه
پیشبینی بقای پنج ساله پیوند کلیه با استفاده از مدل شبکه عصبی مصنوعی: گزارش 22 سال پیگیری از 316 بیمار در اصفهان
Background: Kidney transplantation had been evaluated in some researches in Iran mainly with clinical approach. In this research we evaluated graft survival in kidney recipients and factors impacting on survival rate. Artificial neural networks have a good ability in modeling complex relationships, so we used this ability to demonstrate a model for prediction of 5yr graft survival after ki...
متن کاملComparison of Artificial Neural Networks and Cox Regression Models in Prediction of Kidney Transplant Survival
Cox regression model serves as a statistical method for analyzing the survival data, which requires some options such as hazard proportionality. In recent decades, artificial neural network model has been increasingly applied to predict survival data. This research was conducted to compare Cox regression and artificial neural network models in prediction of kidney transplant survival. The prese...
متن کاملComparison of Artificial Neural Networks and Cox Regression Models in Prediction of Kidney Transplant Survival
Cox regression model serves as a statistical method for analyzing the survival data, which requires some options such as hazard proportionality. In recent decades, artificial neural network model has been increasingly applied to predict survival data. This research was conducted to compare Cox regression and artificial neural network models in prediction of kidney transplant survival. The prese...
متن کاملSurface Tension Prediction of Hydrocarbon Mixtures Using Artificial Neural Network
In this study, artificial neural network was used to predict the surface tension of 20 hydrocarbon mixtures. Experimental data was divided into two parts (70% for training and 30% for testing). Optimal configuration of the network was obtained with minimization of prediction error on testing data. The accuracy of our proposed model was compared with four well-known empirical equations. The arti...
متن کامل